Millions of files related to the late sex offender Jeffrey Epstein suggest the existence of a "global criminal enterprise" that carried out acts meeting the legal threshold of crimes against humanity, according to a panel of independent experts appointed by the United Nations Human Rights Council.

The experts said crimes outlined in documents released by the U.S. Justice Department were committed against a backdrop of supremacist beliefs, racism, corruption and extreme misogyny.

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"So grave is the scale, nature, systematic character, and transnational reach of these atrocities against women and girls, that a number of them may reasonably meet the legal threshold of crimes against humanity," the experts said in a statement.

The experts said the allegations contained in the files require an independent, thorough and impartial investigation, and said inquiries should also be launched into how it was possible for such crimes to be committed for so long.

The U.S. Justice Department did not immediately respond to a request for comment.