Nope.

Two hard-core red states – both will be replaced by Republicans.

Repubs still control the Senate, 51-47. They set the agenda, decide whether a bill moves. There have been very few bills passed this Congress where the outcome would have been different without Graham and McConnell available to vote.

...and while Graham could be quickly replaced, I would think it wouldn't happen that quickly in a state with an outgoing governor with something this big to leverage.

There were 53 repubs and 47 Democrats, including the two independents that vote with the Democrats. Without McConnell and Graham, its 51-47 Fetterman actually is an unreliable vote for the Democrats, so one could argue that it's closer to 52-46. And while some claim that Cornyn and Cassidy aren't reliable votes for the republicans, there is no evidence that they will start supporting Democrats or Democratic positions.

...but I see you've clarified that. In any case, this Senate isn't going to be doing much for the next few months.

But they have 22 more after the election and can do a lot of damage in that lame duck session.

Things are looking up for democrats.

For now, though, it's irrelevant. Get to work flipping seats in your own state. That's what matters.