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Quixote1818

(31,120 posts)
Sun Jun 1, 2025, 06:58 PM Jun 2025

Chronic Cannabis Use, Including Edibles, Linked to Endothelial Dysfunction

This suck as I use edibles to sleep from time to time. Probably going to cut back. I'm 56 and my BP is around 115 over 73 with a resting pulse of 60 to 63. So it doesn't seem like it has done much damage to me yet. Maybe because I exercise a lot and only take 5mg? However, I do notice it causes my heart rate to increase quite a bit until it wears off after 3 hours. Does anyone know of any criticisms of this study?



Chronic Cannabis Use, Including Edibles, Linked to Endothelial Dysfunction

Chronic cannabis use is bad for your heart, whether you smoke it or consume edibles, according to a new study.
Researchers found evidence of endothelial dysfunction, an upstream risk factor for cardiovascular disease, in cannabis users regardless of how they used the substance.
The research adds to a growing body of research suggesting that cannabis is not benign.
New research has linked tetrahydrocannabinol (THC), the psychoactive compound in many cannabis products, to impaired vascular function, a known risk factor for cardiovascular disease.

A growing body of evidenceTrusted Source suggests that smoking THC-containing cannabis likely harms heart health. But far less is known about other forms of cannabis use, such as vaping and edibles.

The use of THC-containing cannabis edibles has surged in popularity as legalization has spread across the United States.

But a new study published on May 28 in JAMA CardiologyTrusted Source suggests that both modes of cannabis consumption — smoking and ingesting — are associated with endothelial dysfunction, comparable to tobacco smoke in healthy adults.

Endothelial dysfunction is a form of heart disease that impairs blood vessels from dilating. Endothelial cells are a thin membrane that lines the inner surface of blood vessels and helps regulate blood flow.

“The bottom line is that smoking marijuana does not appear to avoid the harmful vascular effects of smoking tobacco, and neither does frequent use of THC edibles,” Matthew L. Springer, PhD, professor of medicine at UCSF, and senior author of the research, told Healthline.


More:
More: https://www.healthline.com/health-news/cannabis-edibles-endothelial-dysfunction-cardiovascular-disease

18 replies = new reply since forum marked as read
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Chronic Cannabis Use, Including Edibles, Linked to Endothelial Dysfunction (Original Post) Quixote1818 Jun 2025 OP
I've seen several of these anti pot medical leftyladyfrommo Jun 2025 #1
Thinking you have a VERY good point. Plus, I have abnormal reactions to most Rx, mostly BAD reactions. Attilatheblond Jun 2025 #6
Good points. The fact that my cardivacular health is so good at the very least makes me question Quixote1818 Jun 2025 #7
Long time smoker here and I'm having to have my heart evaluated to see if I can have surgery. lark Jun 2025 #16
Replace the words 'anti pot' with 'pro vaccine' and 'pot works better' with 'ivermectin works better' Celerity Jun 2025 #10
Good point. nt Quixote1818 Jun 2025 #12
Agreed, they want to make it illegal again. Blue Full Moon Jun 2025 #14
Okay but it's the THC, not CBD or CBN. WhiskeyGrinder Jun 2025 #2
You're bumming me out, man. 😁 surfered Jun 2025 #3
The poison is in the dose. multigraincracker Jun 2025 #4
Well, being in so much pain one can walk very little and sleep even less is also gonna screw me up Attilatheblond Jun 2025 #5
Good points on the sleep. There isn't anything much healther than a goodnight sleep. nt Quixote1818 Jun 2025 #8
The one respondent interviewed is absolutely correct in that there is no strong evidence of causality... hlthe2b Jun 2025 #9
Fascinating story k_buddy762 Jun 2025 #11
They keep talkin rickyhall Jun 2025 #13
States that the cannabis does not cause it. Blue Full Moon Jun 2025 #15
Be afraid, be very afraid. WhiteTara Jun 2025 #17
Well, obviously THIS is the single worst possible threat to public health Ursus Rex Jun 2025 #18

leftyladyfrommo

(19,956 posts)
1. I've seen several of these anti pot medical
Sun Jun 1, 2025, 07:03 PM
Jun 2025

reports lately. I am suspicious of these.

I think big pharma puts these out because pot works better than their expensive drugs for pain with little or no serious side effects.

Attilatheblond

(8,294 posts)
6. Thinking you have a VERY good point. Plus, I have abnormal reactions to most Rx, mostly BAD reactions.
Sun Jun 1, 2025, 07:19 PM
Jun 2025

Never used pot until just the past 2 years. Sleep in essential and I wasn't getting enough for months at a time. Daughter took me to dispensary for Mother's Day 2 years ago, to get some gummies to try. Do I have a great daughter or what!

Now, I am not as cranky, depressed, clumsy, and run down. More energy to do the PT I need to keep the pain under control and get a little work done.

Praise the herb, and pass more common sense laws!

Quixote1818

(31,120 posts)
7. Good points. The fact that my cardivacular health is so good at the very least makes me question
Sun Jun 1, 2025, 07:29 PM
Jun 2025

if it has much effect on me personally. However, I know one person does not make a study. I haven't ever seen any studies suggesting pot users don't live as long.

lark

(25,896 posts)
16. Long time smoker here and I'm having to have my heart evaluated to see if I can have surgery.
Mon Jun 2, 2025, 10:47 AM
Jun 2025

EKG showed some possible abnormalities (maybe a murmur in left ventricle?) so surgery is delayed for me to get approved for a stress test. One of my best friends is also a long time smoker and had some heart issues - but an ablation fixed her right up and she's doing great now. Heart disease doesn't run in the family, but I do smoke about 2 grams a day now. I had the echo done, now waiting for auth for the stress test. Since my left shoulder is so bad (reason I need surgery) I can't do the treadmill and have to do the chemical version with an IV - boo!!

I've thought about trying to quit but then I'd be back to where I used to be and wouldn't sleep. Narcotics don't work well on me and I hate the hung over feeling. If I could find a better sleep method not involving thc, I'd use it. Guess I'll just wait and see what happens when I have the test and what the heart docs say about it and consider any changes I need to make afterwards. Sigh.

I really just want my super torn up shoulder to work again and my arm to not "kill" me if I accidentally move it wrong. That is what I am waiting for - getting my bone spurs removed and the muscles repaired.

Celerity

(53,698 posts)
10. Replace the words 'anti pot' with 'pro vaccine' and 'pot works better' with 'ivermectin works better'
Sun Jun 1, 2025, 07:51 PM
Jun 2025

and your argument structure doesn't face up so well.

Attilatheblond

(8,294 posts)
5. Well, being in so much pain one can walk very little and sleep even less is also gonna screw me up
Sun Jun 1, 2025, 07:12 PM
Jun 2025

so....

Never smoked, beyond living in the blue haze that was just about everywhere but school as I grew up, only taking on coffee a day, drinking lots of good water and scoffing down a wide variety of veggies and some fruits. Arthritis making sleep nearly impossible, now THAT was making me frail and failing.

Sleeping better sure makes things work better. I will keep taking my 1 mg thc gummy with other cannabinoids (broad spectrum).

As Senator Joni Ernst said, I'm gonna die no matter what. But I don't see a point in losing my mental faculties due to lack of proper rest in the meantime. I mean, I am 72 unlikely to live much longer, but cardiologist says the ticker is in real good shape. Just had healthy supper of caesar salad and popcorn.

hlthe2b

(112,818 posts)
9. The one respondent interviewed is absolutely correct in that there is no strong evidence of causality...
Sun Jun 1, 2025, 07:37 PM
Jun 2025

A lot of confounding factors have not been controlled for, it is not clear that temporality (ie., that exposure fully or largely precedes the outcome and that the study has controlled for preexisting cardiac risk factors or actual early disease. Further, there seems to be little attempt to quantify and compare dose, and certainly not a dose-effect" that would be expected (i.e., those with the highest exposure have the highest risk, and it follows a linear relationship from low exposure-low risk, moderate exposure-moderate risk...)

These are really only hypothesis-generating studies that should be followed by very well-controlled cohort studies. Still, based on these preliminary findings, perhaps it should give those with significant pre-existing cardiovascular risk factors some pause. For sleep purposes, maybe consider CBD (typically sans significant THC) gummies--maybe with low doses of melatonin added as an alternative for sleep.

I regret that--like nearly every other area of medicine and health--Trump will pose a tremendous obstacle to further studies that should be done.

 

k_buddy762

(638 posts)
11. Fascinating story
Sun Jun 1, 2025, 08:05 PM
Jun 2025

I would like to know more. My entire lifestyle revolved almost solely around maintaining and improving mitochondrial health, and this study overlaps with that biology quite nicely. I have been told by neighbors that members of their families use edibles for migraines and other sorts of chronic pain relief.

Blue Full Moon

(3,164 posts)
15. States that the cannabis does not cause it.
Sun Jun 1, 2025, 11:45 PM
Jun 2025

Your risk is higher if you have:

Diabetes.
High blood pressure (hypertension).
High blood sugar (hyperglycemia).
High cholesterol.
Metabolic syndrome.
Smoking.
Obesity.
Certain autoimmune diseases.

Now that I looked it up. I know a lot of people that have it and none of them use pot. But they do smoke, over weight and have diabetes.

Ursus Rex

(473 posts)
18. Well, obviously THIS is the single worst possible threat to public health
Mon Jun 2, 2025, 12:08 PM
Jun 2025

... not any kind of metabolic, environmental, or other lifestyle factor. We should be able to reduce it fantastically by banning weed, right?

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